Increased levels of circulating platelet-derived microparticles are associated with metastatic cutaneous melanoma
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Increased levels of circulating platelet-derived microparticles are associated with metastatic cutaneous melanoma |
| Type de publication | Journal Article |
| Year of Publication | 2017 |
| Auteurs | Moreau J, Pelletier F, Biichle S, Mourey G, Puyraveau M, Badet N, Caubet M, Laresche C, Garnache-Ottou F, Saas P, Seilles E, Aubin F |
| Journal | EXPERIMENTAL DERMATOLOGY |
| Volume | 26 |
| Pagination | 961-963 |
| Date Published | OCT |
| Type of Article | Article |
| ISSN | 0906-6705 |
| Mots-clés | Melanoma, platelet-derived microparticles, platelets, thrombogenic activity, tumor burden |
| Résumé | {We investigated the plasma levels of PMPs in patients with 45 stage III and 45 stage IV melanoma. PMPs were characterised by flow cytometry and their thrombogenic activity. We also investigated the link between PMPs circulating levels and tumor burden. The circulating levels of PMPs were significantly higher in stage IV (8500 mu L-1) than in patients with stage III (2041 mu L-1) melanoma (P=.0001). We calculated a highly specific (93.3%) and predictive (91.7%) cut-off value (5311 mu L-1) allowing the distinction between high-risk stage III and metastatic stage IV melanoma. The thrombogenic activity of PMPs was significantly higher in patients with stage IV melanoma (clotting time: 40.7second vs 65second |
| DOI | 10.1111/exd.13339 |