Protecting group-free radical decarboxylation of bile acids: Synthesis of novel steroidal substituted maleic anhydrides and maleimides and evaluation of their cytotoxicity on C6 rat glioma cells
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Protecting group-free radical decarboxylation of bile acids: Synthesis of novel steroidal substituted maleic anhydrides and maleimides and evaluation of their cytotoxicity on C6 rat glioma cells |
| Type de publication | Journal Article |
| Year of Publication | 2017 |
| Auteurs | Samadi M, Nury T, Khalafi-Nezhad A, Lizard G |
| Journal | STEROIDS |
| Volume | 125 |
| Pagination | 124-130 |
| Date Published | SEP |
| Type of Article | Article |
| ISSN | 0039-128X |
| Mots-clés | Barton decarboxylation, Bile acids, C6 rat glioma cells, Cytotoxic activity, Steroidal maleic anhydrides, Steroidal maleimide |
| Résumé | We report the first Barton radical decarboxylation of unprotected bile acids via in situ irradiation of their thiohydroxamic esters in the presence of citraconic anhydride and citracoimide, leading to the synthesis a series of steroidal maleic anhydrides and maleimides as novel hybrid bile acids. The cytotoxic activities were evaluated on C6 rat glioma cells. |
| DOI | 10.1016/j.steroids.2017.07.004 |