Increased Levels of Interleukin-17A Exosomes in Psoriasis
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Increased Levels of Interleukin-17A Exosomes in Psoriasis |
| Type de publication | Journal Article |
| Year of Publication | 2019 |
| Auteurs | Jacquin-Porretaz C, Cordonnier M, Nardin C, Boullerot L, Chanteloup G, Vautrot V, Adotevi O, Garrido C, Gobbo J, Aubin F |
| Journal | ACTA DERMATO-VENEREOLOGICA |
| Volume | 99 |
| Pagination | 1143-1147 |
| Date Published | NOV |
| Type of Article | Article |
| ISSN | 0001-5555 |
| Mots-clés | exosomes, IL-17, Psoriasis |
| Résumé | {Exosomes are involved in modulating the immune system and mediating communication between cells. The aim of this study was to investigate the involvement of exosomes in psoriasis. Exosomes from patients with psoriasis were analysed by nanoparticle tracking analysis and protein expression was analysed by western blotting. The concentration of HSP70 was determined by an enzyme-linked immunosorbent assay, and concentrations of interleukin (IL)-1 beta, IL-2, IL-6, IL-10, IL-17A and tumour necrosis factor alpha (TNF-alpha) were determined by flow cytometry. Based on the severity of psoriasis, evaluated by body surface area (<= 10% vs. > 10%), 2 groups of patients were compared (49 with mild psoriasis and 71 with moderate-to-severe psoriasis). The number (2.52x10(11) +/- 2.29x10(10) vs. 1.79x10(11) +/- 1.93x10(10) |
| DOI | 10.2340/00015555-3300 |