Multi-target 1,4-dihydropyridines showing calcium channel blockade and antioxidant capacity for Alzheimer's disease therapy
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Multi-target 1,4-dihydropyridines showing calcium channel blockade and antioxidant capacity for Alzheimer's disease therapy |
| Type de publication | Journal Article |
| Year of Publication | 2019 |
| Auteurs | Malek R, Maj M, Wnorowski A, Jozwiak K, Martin H, Iriepa I, Moraleda I, Chabchoub F, Marco-Contelles J, Ismaili L |
| Journal | BIOORGANIC CHEMISTRY |
| Volume | 91 |
| Pagination | 103205 |
| Date Published | OCT |
| Type of Article | Article |
| ISSN | 0045-2068 |
| Mots-clés | 1, 4-Dihydropyridines, Alzheimer's disease, antioxidants, Calcium channel blockers, Hantzsch multicomponent reaction |
| Résumé | In this work we describe the synthesis, Ca+2 channel blockade capacity and antioxidant power of N-3, N-5-bis(2-(5-methoxy-1H-indol-3-yl) ethyl)-2,6-dimethyl-4-aryl-1,4-dihydropyridine-3,5-dicarboxamides 1-9, a number of multi-target small 1,4-dihydropyridines (DHP), designed by juxtaposition of melatonin and nimodipine. As a result, we have identified antioxidant DHP 7 (Ca2+ channel blockade: 55%, and 8.78 Trolox/Equivalents), the most balanced DHP analyzed here, for potential Alzheimer's disease therapy. |
| DOI | 10.1016/j.bioorg.2019.103205 |