Influence of Molecular Status on Recurrence Site in Patients Treated for a Stage III Colon Cancer: a Post Hoc Analysis of the PETACC-8 Trial
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| Titre | Influence of Molecular Status on Recurrence Site in Patients Treated for a Stage III Colon Cancer: a Post Hoc Analysis of the PETACC-8 Trial |
| Type de publication | Journal Article |
| Year of Publication | 2019 |
| Auteurs | Bruzzi M., Auclin E., R. Dico L, Voron T., Karoui M., Espin E., Cianchi F., Weitz J., Buggenhout A., Malafosse R., Denimal F., Le Malicot K., Vernerey D., Douard R., Emile J.F, Lepage C., Laurent-Puig P., Taieb J. |
| Journal | ANNALS OF SURGICAL ONCOLOGY |
| Volume | 26 |
| Pagination | 3561-3567 |
| Date Published | OCT |
| Type of Article | Article |
| ISSN | 1068-9265 |
| Résumé | {Background Recurrence patterns in stage III colon cancer (CC) patients according to molecular markers remain unclear. The objective of the study was to assess recurrence patterns according to microsatellite instability (MSI), RAS and BRAF(V600E) status in stage III CC patients. Methods All stage III CC patients from the PETACC-8 randomized trial tested for MSI, RAS and BRAF(V600E) status were included. The site and characteristics of recurrence were analyzed according to molecular status. Survival after recurrence (SAR) was analyzed. Results A total of 1650 patients were included. Recurrence occurred in 434 patients (26.3%). Microsatellite stable (MSS) patients had a significantly higher recurrence rate (27.2% vs. 18.7% |
| DOI | 10.1245/s10434-019-07513-6 |