Functionalization of theranostic AGuIX (R) nanoparticles for PET/MRI/optical imaging
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Functionalization of theranostic AGuIX (R) nanoparticles for PET/MRI/optical imaging |
| Type de publication | Journal Article |
| Year of Publication | 2019 |
| Auteurs | Thakare V, Tran V-L, Natuzzi M, Thomas E, Moreau M, Romieu A, Collin B, Courteau A, Vrigneaud J-M, Louis C, Roux S, Boschetti F, Tillement O, Lux F, Denat F |
| Journal | RSC ADVANCES |
| Volume | 9 |
| Pagination | 24811-24815 |
| Date Published | AUG 12 |
| Type of Article | Article |
| Résumé | A novel trifunctional imaging probe containing a chelator of radiometal for PET, a NIR heptamethine cyanine dye, and a bioconjugatable handle, has been grafted onto AGuIX (R) nanoparticles via a Michael addition reaction. The resulting functionalized nanoparticles have been fully characterized, radiolabelled with Cu-64, and evaluated in a mice TSA tumor model using multimodal (PET/MRI/optical) imaging. |
| DOI | 10.1039/c9ra00365g |