Zizyphus lotus L. fruit attenuates obesity-associated alterations: in vivo mechanisms

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TitreZizyphus lotus L. fruit attenuates obesity-associated alterations: in vivo mechanisms
Type de publicationJournal Article
Year of PublicationSubmitted
AuteursBerrichi M, Benammar C, Murtaza B, Hichami A, Belarbi M, Khan NAkhtar
JournalARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
Type of ArticleArticle; Early Access
ISSN1381-3455
Mots-clésHigh-fat diet, inflammation, insulin, Obesity, Zizyphus lotus L
Résumé

Context: Zizyphus lotus L., ZL is a Mediterranean plant and widely consumed for its beneficial medicinal properties. Objective: We assessed the effects of ZL fruit on diet-induced obesity. Materials and methods: Male C57BL/6j mice were divided into three groups. Each group received either a standard diet or a high-fat diet, HFD (30% of palm oil, w/v) or a HFD-supplemented with ZL fruit powder (10%, w/w) for six weeks, followed by a six weeks period, in which animals were maintained on the HFD and ZL aqueous extract (1%, w/v). We measured plasma parameters and assessed the expression of key genes involved in energy metabolism and inflammation. Results: ZL fruit improved glycaemia, lipids concentrations and inflammation in obese mice. Discussion and conclusion: Our investigations showed that ZL fruit improved glucose tolerance, dyslipidaemia and fatty liver disease, but not the severity of HFD-induced obesity in mice.

DOI10.1080/13813455.2019.1621349, Early Access Date = {JUN 2019