Contribution of rare coding mutations in CD36 to type 2 diabetes and cardio-metabolic complications
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Contribution of rare coding mutations in CD36 to type 2 diabetes and cardio-metabolic complications |
| Type de publication | Journal Article |
| Year of Publication | 2019 |
| Auteurs | Meyre D, Andress EJ, Sharma T, Snippe M, Asif H, Maharaj A, Vatin V, Gaget S, Besnard P, Choquet H, Froguel P, Linton KJ |
| Journal | SCIENTIFIC REPORTS |
| Volume | 9 |
| Pagination | 17123 |
| Date Published | NOV 20 |
| Type of Article | Article |
| ISSN | 2045-2322 |
| Résumé | {We sequenced coding regions of the cluster of differentiation 36 (CD36) gene in 184 French individuals of European ancestry presenting simultaneously with type 2 diabetes (T2D), arterial hypertension, dyslipidemia, and coronary heart disease. We identified rare missense mutations (p.Pro191Leu/rs143150225 and p.Ala252Val/rs147624636) in two heterozygous cases. The two CD36 mutation carriers had no family history of T2D and no clustering of cardio-metabolic complications. While the p.Pro191Leu mutation was found in 84 heterozygous carriers from five ethnic groups from the genome aggregation database (global frequency: 0.0297% |
| DOI | 10.1038/s41598-019-53388-8 |