Highly antiproliferative neutral Ru(II)-arene phosphine complexes
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Highly antiproliferative neutral Ru(II)-arene phosphine complexes |
| Type de publication | Journal Article |
| Year of Publication | 2018 |
| Auteurs | Chotard F, Dondaine L, Balan C, Bettaieb A, Paul C, Le Gendre P, Bodio E |
| Journal | NEW JOURNAL OF CHEMISTRY |
| Volume | 42 |
| Pagination | 8105-8112 |
| Date Published | MAY 21 |
| Type of Article | Article; Proceedings Paper |
| ISSN | 1144-0546 |
| Résumé | Six ruthenium(II)- and four gold(I)-phosphine based complexes were synthesized and fully characterized. Some of them displayed strong antiproliferative properties for several types of cancer including colon, breast, and lung. Notably, two of the Ru(II) complexes displayed an IC50 of around 2 mM, which is exceptional for these types of complexes. The dramatic impact of the nature of the arene coordinated on the ruthenium center was clearly evidenced. |
| DOI | 10.1039/c7nj04442a |