Constitutive Activation of MexT by Amino Acid Substitutions Results in MexEF-OprN Overproduction in Clinical Isolates of Pseudomonas aeruginosa
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Constitutive Activation of MexT by Amino Acid Substitutions Results in MexEF-OprN Overproduction in Clinical Isolates of Pseudomonas aeruginosa |
| Type de publication | Journal Article |
| Year of Publication | 2018 |
| Auteurs | Juarez P, Broutin I, Bordi C, Plesiat P, Llanes C |
| Journal | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY |
| Volume | 62 |
| Pagination | e02445-17 |
| Date Published | MAY |
| Type of Article | Article |
| ISSN | 0066-4804 |
| Mots-clés | Antibiotic resistance, MexEF-OprN, MexT, Pseudomonas aeruginosa |
| Résumé | When overproduced, the multidrug efflux system MexEF-OprN increases the resistance of Pseudomonas aeruginosa to fluoroquinolones, chloramphenicol, and trimethoprim. In this work, we demonstrate that gain-of-function mutations in the regulatory gene mexT result in oligomerization of the LysR regulator MexT, constitutive upregulation of the efflux pump, and increased resistance in clinical isolates. |
| DOI | 10.1128/AAC.02445-17 |