LPCAT2 controls chemoresistance in colorectal cancer
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | LPCAT2 controls chemoresistance in colorectal cancer |
| Type de publication | Journal Article |
| Year of Publication | 2018 |
| Auteurs | Cotte AKaren, Aires V, Ghiringhelli F, Delmas D |
| Journal | MOLECULAR & CELLULAR ONCOLOGY |
| Volume | 5 |
| Pagination | e1448245 |
| Type of Article | Article |
| ISSN | 2372-3556 |
| Mots-clés | chemoresistance, Colorectal cancer, immunogenic cell death, Lipid droplets, LPCAT2 |
| Résumé | Lipid droplets (LD) are now-well recognized as playing a role in cancer progression, however their potential role in chemoresistance remains largely unknown, particularly in colorectal cancer (CRC). We recently highlighted that LD accumulate in CRC cells under the control of lysophosphatidylcholine acyltransferase 2 (LPCAT2) enzyme expression. We also showed that chemotherapy-induced LD accumulation counteracts intrinsic and extrinsic cancer cell death activation. |
| DOI | 10.1080/23723556.2018.1448245 |