Is laterality of congenital diaphragmatic hernia a reliable prognostic factor? French national cohort study

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TitreIs laterality of congenital diaphragmatic hernia a reliable prognostic factor? French national cohort study
Type de publicationJournal Article
Year of Publication2020
AuteursPinton A, Boubnova J, Becmeur F, Kuhn P, Senat M-V, Stirnemann J, Capelle M, Rosenblatt J, Massardier J, Vaast P, Le Bouar G, Desrumaux A, Connant L, Begue L, Parmentier B, Perrotin F, Diguet A, Benoist G, Muszynski C, Scalabre A, Winer N, Michel J-L, Casagrandre-Magne F, Jouannic J-M, Gallot D, Mazeau PCoste, Sapin E, Maatouk A, Saliou A-H, Sentilhes L, Biquard F, Mottet N, Favre R, Benachi A, Sananes N
JournalPRENATAL DIAGNOSIS
Volume40
Pagination949-957
Date PublishedJUL
Type of ArticleArticle
ISSN0197-3851
Résumé

{Objectives The objective of this study was to assess whether the laterality of congenital diaphragmatic hernia (CDH) was a prognostic factor for neonatal survival. Methods This was a cohort study using the French national database of the Reference Center for Diaphragmatic Hernias. The principal endpoint was survival after hospitalization in intensive care. We made a comparative study between right CDH and left CDH by univariate and multivariate analysis. Terminations and stillbirths were excluded from analyses of neonatal outcomes. Results A total of 506 CDH were included with 67 (13%) right CDH and 439 left CDH (87%). Rate of survival was 49% for right CDH and 74% for left CDH (P < .01). Multivariate analysis showed two factors significantly associated with mortality: thoracic herniation of liver (OR 2.27; IC 95% [1.07-4.76]; P = .03) and lung-to-head-ratio over under expected (OR 2.99; IC 95% [1.41-6.36]; P < .01). Side of CDH was not significantly associated with mortality (OR 1.87; IC 95% [0.61-5.51]
DOI10.1002/pd.5706, Early Access Date = {MAY 2020