Single-nucleotide polymorphism rs1761667 in the CD36 gene is associated with orosensory perception of a fatty acid in obese and normal-weight Moroccan subjects

Obese subjects have shown a preference for dietary lipids. A recent collection of evidence has proposed that a variant in theCD36gene plays a significant role in this pathway. We assessed the association between the orosensory detection of a long-chain fatty acid, i.e. oleic acid (OA), and genetic polymorphism of the lipid taste sensor CD36 in obese and normal-weight subjects. Adult participants were recruited in the fasting condition. They were invited to fat taste perception sessions, using emulsions containing OA and according to the three-alternative forced-choice (3-AFC) method. Genomic DNA was used to determine the polymorphism (SNP rs 1761667) of theCD36gene. Obese (n50; BMI 34.97 (sd4.02) kg/m(2)) exhibited a significantly higher oral detection threshold for OA (3.056 (sd3.53) mmol/l) than did the normal-weight (n50; BMI 22.16 (sd1.81) kg/m(2)) participants (1.20 (sd3.23) mmol/l;P= 0.007). There was a positive correlation between OA detection thresholds and BMI in all subjects; evenly with body fat percentage (BF%). AA genotype was more frequent in the obese group than normal-weight group. OA detection thresholds were much higher for AA and AG genotypes in obese subjects compared with normal-weight participants. Higher oral detection thresholds for fatty acid taste are related to BMI, BF% and not always toCD36genotype.