Impact of the route of nutrition on gut mucosa in ventilated adults with shock: an ancillary of the NUTRIREA-2 trial
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Impact of the route of nutrition on gut mucosa in ventilated adults with shock: an ancillary of the NUTRIREA-2 trial |
| Type de publication | Journal Article |
| Year of Publication | 2019 |
| Auteurs | Piton G, Le Gouge A, Brule N, Cypriani B, Lacherade J-C, Nseir S, Mira J-P, Mercier E, Sirodot M, Rigaud J-P, Malaquin S, Soum E, Djibre M, Gaudry S, Thevenin D, Reignier J |
| Journal | INTENSIVE CARE MEDICINE |
| Volume | 45 |
| Pagination | 948-956 |
| Date Published | JUL |
| Type of Article | Article |
| ISSN | 0342-4642 |
| Mots-clés | Enteral nutrition, Parenteral nutrition, Plasma citrulline, Plasma intestinal fatty acid binding protein |
| Résumé | {PurposeThe effects of the route of nutrition on the gut mucosa of patients with shock are unclear. Plasma citrulline concentration is a marker of enterocyte mass, and plasma intestinal fatty acid binding protein (I-FABP) concentration is a marker of enterocyte damage. We aimed to study the effect of the route of nutrition on plasma citrulline concentration measured at day3 of nutrition.Materials and methodsAncillary study of the NUTRIREA-2 trial. Ventilated adults with shock were randomly assigned to receive enteral or parenteral nutrition. Enterocyte biomarkers were measured at baseline, day3, and day8 of nutrition.ResultA total of 165 patients from 13 French ICUs were included in the study: 85 patients in the enteral group and 80 patients in the parenteral group. At baseline, plasma citrulline was low without difference between groups (12.2 mu molL(-1) vs 13.3 mu molL(-1)). At day3, plasma citrulline concentration was higher in the enteral group than in the parenteral group (18.7 mu molL(-1) vs 15.3 mu molL(-1) |
| DOI | 10.1007/s00134-019-05649-3 |