Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenstrom macroglobulinemia

Affiliation auteurs!!!! Error affiliation !!!!
TitreTwo high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenstrom macroglobulinemia
Type de publicationJournal Article
Year of Publication2018
AuteursMcMaster ML, , Zhang J, Slager SL, Li SAlfred, Vajdic CM, Smedby KE, Yan H, Birmann BM, Brown EE, Smith A, Kleinstern G, Fansler MM, Mayr C, Zhu B, Chung CC, Park J-H, Burdette L, Hicks BD, Hutchinson A, Teras LR, Adami H-O, Bracci PM, Mckay J, Monnereau A, Link BK, Vermeulen RCH, Ansell SM, Maria A, W. Diver R, Melbye M, , Kraft P, Boffetta P, Clavel J, Giovannucci E, Besson CM, Canzia F, Travis RC, Vineis P, Weiderpass E, Montalvan R, Wang Z, Yeager M, Becker N, Benavente Y, Brennan P, Foretova L, Maynadie M, Nieters A, de Sanjose S, Staines A, Conde L, Riby J, Glimelius B, Hjalgrim H, Pradhan N, Feldman AL, Novak AJ, Lawrence C, Bassig BA, Lan Q, Zheng T, North KE, Tinker LF, Cozen W, Severson RK, Hofmann JN, Zhang Y, Jackson RD, Morton LM, Purdue MP, Chatterjee N, Offit K, Cerhan JR, Chanock SJ, Rothman N, Vijai J, Goldin LR, Skibola CF, Caporaso NE
JournalNATURE COMMUNICATIONS
Volume9
Pagination4182
Date PublishedOCT 10
Type of ArticleArticle
ISSN2041-1723
Résumé

{Waldenstrom macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is a rare, chronic B-cell lymphoma with high heritability. We conduct a two-stage genome-wide association study of WM/LPL in 530 unrelated cases and 4362 controls of European ancestry and identify two high-risk loci associated with WM/LPL at 6p25.3 (rs116446171, near EXOC2 and IRF4; OR = 21.14, 95% CI: 14.40-31.03
DOI10.1038/s41467-018-06541-2