Impact of cerebro-spinal fluid biomarkers of Alzheimer's disease in clinical practice: a multicentric study
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Impact of cerebro-spinal fluid biomarkers of Alzheimer's disease in clinical practice: a multicentric study |
| Type de publication | Journal Article |
| Year of Publication | 2014 |
| Auteurs | Mouton-Liger F, Wallon D, Troussiere A-C, Yatimi R, Dumurgier J, Magnin E, de la Sayette V, Duron E, Philippi N, Beaufils E, Gabelle A, Croisile B, Robert P, Pasquier F, Hannequin D, Hugon J, Paquet C |
| Journal | JOURNAL OF NEUROLOGY |
| Volume | 261 |
| Pagination | 144-151 |
| Date Published | JAN |
| Type of Article | Article |
| ISSN | 0340-5354 |
| Mots-clés | Alzheimer's disease, biomarkers, Cerebrospinal fluid, Clinical practice |
| Résumé | {CSF biomarkers of Alzheimer's disease are well validated in clinical research; however, their pragmatic utility in daily practice is still unappreciated. These biomarkers are used in routine practice according to Health Authority Recommendations. In 604 consecutive patients explored for cognitive disorders, questionnaires were prospectively proposed and filled. Before and after CSF biomarker results, clinicians provided a diagnosis and an estimate of their diagnostic confidence. Analysis has compared the frequency of diagnosis before and after CSF biomarker results using the net reclassification improvement (NRI) method. We have evaluated external validity comparing with data of French Bank National of AD (BNA). A total of 561 patients [Alzheimer's disease (AD) |
| DOI | 10.1007/s00415-013-7160-3 |