Estrogen receptor polymorphisms and incident dementia: The prospective 3C study
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Estrogen receptor polymorphisms and incident dementia: The prospective 3C study |
| Type de publication | Journal Article |
| Year of Publication | 2014 |
| Auteurs | Ryan J, Carriere I, Carcaillon L, Dartigues J-F, Auriacombe S, Rouaud O, Berr C, Ritchie K, Scarabin P-Y, Ancelin M-L |
| Journal | ALZHEIMERS & DEMENTIA |
| Volume | 10 |
| Pagination | 27-35 |
| Date Published | JAN |
| Type of Article | Article |
| ISSN | 1552-5260 |
| Mots-clés | Alzheimer's disease, ApoE, cohort study, Dementia, epidemiology, ESR1, ESR2, Estrogen receptor polymorphisms, Gender-specific |
| Résumé | {Background: Genetic variation in the estrogen receptor (ESR) may be associated with the incidence of Alzheimer's disease (AD), but this association could be modified by genetic and environmental factors. Methods: The association between five ESR alpha (ESR1) and beta (ESR2) polymorphisms with 7-year dementia incidence was examined among 6959 older men and women from the Three City Study using multivariate-adjusted Cox regression models with delayed entry. Gender, the apolipoprotein E (APOE) epsilon 4 allele, and hormone treatment were considered as potential effect modifiers of this association. Results: Among women, the CC genotype of ESR1 rs2234693 was specifically associated with a small increased risk of AD (adjusted hazard ratio [HR]: 1.54, 95% confidence interval [CI]: 1.03-2.28 |
| DOI | 10.1016/j.jalz.2012.12.008 |