Serum 2-Hydroxyglutarate Production in IDH1- and IDH2-Mutated De Novo Acute Myeloid Leukemia: A Study by the Acute Leukemia French Association Group
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Serum 2-Hydroxyglutarate Production in IDH1- and IDH2-Mutated De Novo Acute Myeloid Leukemia: A Study by the Acute Leukemia French Association Group |
| Type de publication | Journal Article |
| Year of Publication | 2014 |
| Auteurs | Janin M, Mylonas E, Saada V, Micol J-B, Renneville A, Quivoron C, Koscielny S, Scourzic L, Forget S, Pautas C, Caillot D, Preudhomme C, Dombret H, Berthon C, Barouki R, Rabier D, Auger N, Griscelli F, Chachaty E, Leclercq E, Courtier M-H, Bennaceur-Griscelli A, Solary E, Bernard OAdrien, Penard-Lacronique V, Ottolenghi C, de Botton S |
| Journal | JOURNAL OF CLINICAL ONCOLOGY |
| Volume | 32 |
| Pagination | 297+ |
| Date Published | FEB 1 |
| Type of Article | Article |
| ISSN | 0732-183X |
| Résumé | {Purpose Mutated isocitrate dehydrogenases (IDHs) 1 and 2 produce high levels of 2-hydroxyglutarate (2-HG). We investigated whether, in acute myeloid leukemia (AML), serum 2-HG would predict the presence of IDH1/2 mutations at diagnosis and provide a marker of minimal residual disease (MRD). Patients and Methods Serum samples from 82 patients at diagnosis of de novo AML (IDH1/2 mutated |
| DOI | 10.1200/JCO.2013.50.2047 |