Early postoperative prophylactic noninvasive ventilation after major lung resection in COPD patients: a randomized controlled trial

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TitreEarly postoperative prophylactic noninvasive ventilation after major lung resection in COPD patients: a randomized controlled trial
Type de publicationJournal Article
Year of Publication2014
AuteursLorut C, Lefebvre A, Planquette B, Quinquis L, Clavier H, Santelmo N, Hanna HAbou, Bellenot F, Regnard J-F, Riquet M, Magdeleinat P, Meyer G, Roche N, Huchon G, Coste J, Rabbat A
JournalINTENSIVE CARE MEDICINE
Volume40
Pagination220-227
Date PublishedFEB
Type of ArticleArticle
ISSN0342-4642
Mots-clésAcute respiratory failure, COPD, Non-invasive ventilation, postoperative care, Thoracic surgery
Résumé

{Objectives: To investigate whether prophylactic postoperative NIV prevents respiratory complications following lung resection surgery in COPD patients. Methods: In seven thoracic surgery departments, 360 COPD patients undergoing lung resection surgery were randomly assigned to two groups: conventional postoperative treatment without (n = 179) or with (n = 181) prophylactic NIV, applied intermittently during 6 h per day for 48 h following surgery. The primary endpoint was the rate of acute respiratory events (ARE) at 30 days postoperatively (ITT analysis). Secondary endpoints were acute respiratory failure (ARF), intubation rate, mortality rate, infectious and non-infectious complications, and duration of ICU and hospital stay. Measurements and main results: ARE rates did not differ between the prophylactic NIV and control groups (57/181, 31.5 vs. 55/179, 30.7 %
DOI10.1007/s00134-013-3150-2