Tumor microenvironment: regulatory cells and immunosuppressive cytokines

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TitreTumor microenvironment: regulatory cells and immunosuppressive cytokines
Type de publicationJournal Article
Year of Publication2014
AuteursBruchard M, Ghiringhelli F
JournalM S-MEDECINE SCIENCES
Volume30
Pagination429–435
Date PublishedAPR
Type of ArticleReview
ISSN0767-0974
Résumé

Immunosuppression is a mechanism developed by cancer cells to help them escape the immune system. Immunosuppression involves expansion of various cell types and production of a variety of cytokines. In this review, we explore the duality of three cancer induced cell populations, regulatory T lymphocytes, Th17 lymphocytes and MDSC, and also the pleiotropic effects of several cytokines induced during cancer development.

DOI10.1051/medsci/20143004018