Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade

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TitreGenetic variation in mitotic regulatory pathway genes is associated with breast tumor grade
Type de publicationJournal Article
Year of Publication2014
AuteursPurrington KS, Slettedahl S, Bolla MK, Michailidou K, Czene K, Nevanlinna H, Bojesen SE, Andrulis IL, Cox A, Hall P et al.
JournalHUMAN MOLECULAR GENETICS
Volume23
Pagination6034-6046
Date PublishedNOV 15
Type of ArticleArticle
ISSN0964-6906
Résumé

{Mitotic index is an important component of histologic grade and has an etiologic role in breast tumorigenesis. Several small candidate gene studies have reported associations between variation in mitotic genes and breast cancer risk. We measured associations between 2156 single nucleotide polymorphisms (SNPs) from 194 mitotic genes and breast cancer risk, overall and by histologic grade, in the Breast Cancer Association Consortium (BCAC) iCOGS study (n = 39 067 cases; n = 42 106 controls). SNPs in TACC2 [rs17550038: odds ratio (OR) = 1.24, 95% confidence interval (CI) 1.16-1.33
DOI10.1093/hmg/ddu300