Effect of albumin in cirrhotic patients with infection other than spontaneous bacterial peritonitis. A randomized trial

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TitreEffect of albumin in cirrhotic patients with infection other than spontaneous bacterial peritonitis. A randomized trial
Type de publicationJournal Article
Year of Publication2015
AuteursThevenot T, Bureau C, Oberti F, Anty R, Louvet A, Plessier A, Rudler M, Heurgue-Berlot A, Rosa I, Talbodec N, Dao T, Ozenne V, Carbonell N, Causse X, Goria O, Minello A, de Ledinghen V, Amathieu R, Barraud H, Nguyen-Khac E, Becker C, Paupard T, Botta-Fridlung D, Abdelli N, Guillemot F, Monnet E, Di Martino V
JournalJOURNAL OF HEPATOLOGY
Volume62
Pagination822-830
Date PublishedAPR
Type of ArticleArticle
ISSN0168-8278
Mots-clésLiver cirrhosis, portal hypertension, prognosis, Renal failure, sepsis
Résumé

{Background & Aims: Albumin infusion improves renal function and survival in cirrhotic patients with spontaneous bacterial peritonitis (SBP) but its efficacy in other types of infections remains unknown. We investigated this issue through a multicenter randomized controlled trial. Methods: A total of 193 cirrhotic patients with a Child-Pugh score greater than 8 and sepsis unrelated to SBP were randomly assigned to receive antibiotics plus albumin (1.5 g/kg on day 1 and 1 g/kg on day 3; albumin group [ALB]: n = 96) or antibiotics alone (control group [CG]: n = 97). The primary endpoint was the 3-month renal failure rate (increase in creatinine >= 50% to reach a final value >= 133 mu mol/L). The secondary endpoint was 3-month survival rate. Results: Forty-seven (24.6%) patients died (ALB: n = 27 vs. CG: n = 20; 3-month survival: 70.2% vs. 78.3%; p = 0.16). Albumin infusion delayed the occurrence of renal failure (mean time to onset, ALB: 29.0 +/- 21.8 vs. 11.7 +/- 9.1 days
DOI10.1016/j.jhep.2014.11.017