ROTAVIRUS VACCINE VIRUS SHEDDING, VIREMIA AND CLEARANCE IN INFANTS WITH SEVERE COMBINED IMMUNE DEFICIENCY

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TitreROTAVIRUS VACCINE VIRUS SHEDDING, VIREMIA AND CLEARANCE IN INFANTS WITH SEVERE COMBINED IMMUNE DEFICIENCY
Type de publicationJournal Article
Year of Publication2015
AuteursKaplon J, Cros G, Ambert-Balay K, Leruez-Ville M, Chomton M, Fremy C, Pothier P, Blanche S
JournalPEDIATRIC INFECTIOUS DISEASE JOURNAL
Volume34
Pagination326-328
Date PublishedMAR
Type of ArticleArticle
ISSN0891-3668
Mots-clésDiarrhea, rotavirus vaccine, SCID, viremia
Résumé

We report for the first time Rotarix vaccine-acquired rotavirus infections with viremia in 2 infants vaccinated before being diagnosed with severe combined immune deficiency. Monitoring the first infant revealed that persistent rotavirus infection resolved after complete immune reconstitution was achieved by gene therapy.

DOI10.1097/INF.0000000000000560