Involvement of Th17 pathway in spondyloarthritis

Spondyloarthritis is a chronic inflammatory disease, whose pathogeny involves microbial agents, genetic factors and the gut, leading to inflammation in several target tissues. The Th17 pathway corresponds to polarization of CD4 na ve cells towards Th17 cells (producing predominantly IL-17 and IL-22) under `the influence of IL-23, completing the IL-231Th17 axis. This pathway is activated and involved at several levels in spondyloarthritis : microbial contact (microbiota and.dysbiosis), HLA-B27 (misfolding) and gut inflammation. IL-23 receptor expressing cells were found in enthuses of animal model, and migrating from gut to blood, bone marrow and joint in humans. The involvement of this pathway allows insight into targeted therapies against IL-17 or IL-23 in spondyloarthritis.