Comparison of umbilical cord blood allogeneic stem cell transplantation vs. auto-SCT for adult acute myeloid leukemia patients in second complete remission at transplant: a retrospective study on behalf of the SFGM-TC

Affiliation auteurs!!!! Error affiliation !!!!
TitreComparison of umbilical cord blood allogeneic stem cell transplantation vs. auto-SCT for adult acute myeloid leukemia patients in second complete remission at transplant: a retrospective study on behalf of the SFGM-TC
Type de publicationJournal Article
Year of Publication2015
AuteursChevallier P, Labopin M, Socie G, Rubio M-T, Blaise D, Vigouroux S, Huynh A, Michallet M, Bay J-O, Maury S, Yakoub-Agha I, Fegueux N, Deconinck E, Contentin N, Maillard N, Bulabois C-E, Francois S, Oumedaly R, Raus N, Mohty M
JournalEUROPEAN JOURNAL OF HAEMATOLOGY
Volume94
Pagination449-455
Date PublishedMAY
Type of ArticleArticle
ISSN0902-4441
Mots-clésacute myeloid leukemia, autologous stem cell transplant, second complete remission, SFGM-TC, umbilical cord blood allogeneic stem cell transplantation
Résumé

{This retrospective study considered the outcomes of 181 patients with acute myeloid leukemia (AML) transplanted in second complete remission (CR2) between January 2005 and April 2012 and who received either a myeloablative autologous stem cell transplant (Auto-SCT; n=82; median age: 48years; median follow-up: 45months) or an umbilical cord blood (UCB) allogeneic SCT (n=99, median age: 46years; median follow-up: 36months; conditioning regimens: myeloablative n=21, reduced n=78; single unit n=37, double units n=62). Although the Auto group showed a significant better prognostic profile at transplant, with longer median interval between diagnosis and time of graft, higher incidence of good-risk cytogenetics and lower number of previously transplanted patients, 3-year OS and LFS were similar between both groups (Auto: 59 +/- 6% vs. 50 +/- 6%
DOI10.1111/ejh.12451