Impact of Neoadjuvant Chemoradiation on Lymph Node Status in Esophageal Cancer Post hoc Analysis of a Randomized Controlled Trial

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TitreImpact of Neoadjuvant Chemoradiation on Lymph Node Status in Esophageal Cancer Post hoc Analysis of a Randomized Controlled Trial
Type de publicationJournal Article
Year of Publication2015
AuteursRobb WB, Dahan L, Mornex F, Maillard E, Thomas P-A, Meunier B, Boige V, Pezet D, Le Brun-Ly V, Bosset J-F, Mabrut J-Y, Triboulet J-P, Bedenne L, Seitz J-F, Mariette C, Cancerologie FFrancaise, Oncolo SFrancaise, Canc UCtr Lutte, Multidisciplinaire GCooperateu, G FEsoGAstric, Chirurg FRech
JournalANNALS OF SURGERY
Volume261
Pagination902-908
Date PublishedMAY
Type of ArticleArticle
ISSN0003-4932
Mots-clésChemoradiation, Esophageal cancer, Lymph node, Randomized trial, Surgery, survival
Résumé

{Objective: The study objectives were to analyze the impact of the number of lymph nodes (LNs) reported as resected (NLNr) and the number of LNs invaded (NLNi) on the prognosis of esophageal cancer (EC) after neoadjuvant chemoradiotherapy. Background: Pathological LN status is a major disease prognostic factor and marker of surgical quality. The impact of neoadjuvant chemoradiation (nCRT) on LN status remains poorly studied in EC. Methods: Post hoc analysis from a phase III randomized controlled trial comparing nCRT and surgery (group nCRT) to surgery alone (group S) in stage I and II EC (NCT00047112). Only patients who underwent surgical resection were considered (n = 170). Results: nCRT resulted in tumoral downstaging (pT0, 40.7% vs 1.1%, P < 0.001), LN downstaging (pN0, 69.1% vs 47.2%
DOI10.1097/SLA.0000000000000991