Neoadjuvant Treatment in Upper Rectal Cancer Does Not Improve Oncologic Outcomes But Increases Postoperative Morbidity

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TitreNeoadjuvant Treatment in Upper Rectal Cancer Does Not Improve Oncologic Outcomes But Increases Postoperative Morbidity
Type de publicationJournal Article
Year of Publication2020
AuteursTabchouri N, Eid Y, Manceau G, Frontali A, Lakkis Z, Salame E, Lecomte T, Chapet S, Calais G, Heyd B, Karoui M, Alves A, Panis Y, Ouaissi M
JournalANTICANCER RESEARCH
Volume40
Pagination3579-3587
Date PublishedJUN
Type of ArticleArticle
ISSN0250-7005
Mots-cléschemoradiation therapy, long-term functional results, neoadjuvant treatment, recurrence-free and overall survival, Upper rectal cancer
Résumé

{Background/Aim: Neoadjuvant chemoradiation/radiation therapy in locally advanced (LA) upper rectal adenocarcinoma management remains unclear. The aim of this study was to compare outcomes between neoadjuvant chemoradiation therapy (CRT) and upfront surgery (US). Patients and Methods: A total of 127 patients were retrospectively included from 5 centers (79 treated with US and 48 with CRT). CRT and US groups were compared in terms of postoperative complications and long-term oncological and functional results. Results: Total mesorectal excision (TME) was more frequent in CRT (58% vs. 20% in US, p<0.001). CRT was associated with more overall and severe postoperative complications (60% vs. 30%, p<0.001 and 17% vs. 1%
DOI10.21873/anticanres.14348