Antifungal susceptibility testing practices in mycology laboratories in France, 2018

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TitreAntifungal susceptibility testing practices in mycology laboratories in France, 2018
Type de publicationJournal Article
Year of Publication2020
AuteursBellanger A-P, Persat F., Foulet F., Bonnal C., Accoceberry I, Angebault C., Angoulvant A., Augereau O., Bailly E., Bert F., Bonhomme J., Bouchara J-P, Bougnoux M-E, Bourdeau P., Bouteille B., Brun S., Brunet K., Camin-Ravenne A-M, Cassaing S., Chouaki T., Cornet M., Costa D., Desbois N., Dorin J., Fekkar A., Fiacre A., Frealle E., Gangneux J-P, Guillot J., Guitard J., Hasseine L., Huguenin A., Lachaud L., Larreche S., Lavergne R-A, Le Gal S., Le Govic Y., Letscher-Bru V, Machouart M., Mazars E., Nourrisson C., Paugam A., Ranque S., Risco-Castillo V, Sasso M., Sautour M., Sendid B., Senghor Y., Botterel F., Dannaoui E
JournalJOURNAL DE MYCOLOGIE MEDICALE
Volume30
Pagination100970
Date PublishedJUN
Type of ArticleArticle
ISSN1156-5233
Mots-clésAntifungal susceptibility testing, Etest, Laboratory practice, MIC value interpretation
Résumé

A survey of mycology laboratories for antifungal susceptibility testing (AFST) was undertaken in France in 2018, to better understand the difference in practices between the participating centers and to identify the difficulties they may encounter as well as eventual gaps with published standards and guidelines. The survey captured information from 45 mycology laboratories in France on how they perform AFST (number of strains tested, preferred method, technical and quality aspects, interpretation of the MIC values, reading and interpretation difficulties). Results indicated that 86% of respondents used Etest as AFST method, with a combination of one to seven antifungal agents tested. Most of the participating laboratories used similar technical parameters to perform their AFST method and a large majority used, as recommended, internal and external quality assessments. Almost all the participating mycology laboratories (98%) reported difficulties to interpret the MIC values, especially when no clinical breakpoints are available. The survey highlighted that the current AFST practices in France need homogenization, particularly for MIC reading and interpretation. (C) 2020 Elsevier Masson SAS. All rights reserved.
DOI10.1016/j.mycmed.2020.100970