Serial use of pentamidine and miltefosine for treating Leishmania infantum-HIV coinfection
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Titre | Serial use of pentamidine and miltefosine for treating Leishmania infantum-HIV coinfection |
Type de publication | Journal Article |
Year of Publication | 2016 |
Auteurs | Faucher J-F, Morquin D, Reynes J, Chirouze C, Hoen B, Le Moing V |
Journal | PARASITOLOGY INTERNATIONAL |
Volume | 65 |
Pagination | 444-446 |
Date Published | OCT |
Type of Article | Article |
ISSN | 1383-5769 |
Mots-clés | AIDS, Liposomal amphotericin B, Miltefosine, Pentamidine, Visceral leishmaniasis |
Résumé | Liposomal amphotericin B (LAmb) may fail to heal Leishmania infantum visceral leishmaniasis (VL) in the immunodeficient host. There are currently no guidelines on how to treat such patients and efficacy of miltefosine monotherapy seems limited in this indication. We present 2 cases of patients with VL and AIDS for which LAmb had to be interrupted (one because of toxicity, one because of treatment failure) and who were treated effectively with pentamidine followed by miltefosine. (C) 2016 Elsevier Ireland Ltd. All rights reserved. |
DOI | 10.1016/j.parint.2016.06.009 |