Serial use of pentamidine and miltefosine for treating Leishmania infantum-HIV coinfection

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TitreSerial use of pentamidine and miltefosine for treating Leishmania infantum-HIV coinfection
Type de publicationJournal Article
Year of Publication2016
AuteursFaucher J-F, Morquin D, Reynes J, Chirouze C, Hoen B, Le Moing V
JournalPARASITOLOGY INTERNATIONAL
Volume65
Pagination444-446
Date PublishedOCT
Type of ArticleArticle
ISSN1383-5769
Mots-clésAIDS, Liposomal amphotericin B, Miltefosine, Pentamidine, Visceral leishmaniasis
Résumé

Liposomal amphotericin B (LAmb) may fail to heal Leishmania infantum visceral leishmaniasis (VL) in the immunodeficient host. There are currently no guidelines on how to treat such patients and efficacy of miltefosine monotherapy seems limited in this indication. We present 2 cases of patients with VL and AIDS for which LAmb had to be interrupted (one because of toxicity, one because of treatment failure) and who were treated effectively with pentamidine followed by miltefosine. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

DOI10.1016/j.parint.2016.06.009