Long-term efficacy and safety of etravirine-containing regimens in a real-life cohort of treatment-experienced HIV-1-infected patients

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TitreLong-term efficacy and safety of etravirine-containing regimens in a real-life cohort of treatment-experienced HIV-1-infected patients
Type de publicationJournal Article
Year of Publication2016
AuteursAllavena C, Katlama C, Cotte L, Roger PMarie, Delobel P, Cheret A, Duvivier C, Poizot-Martin I, Hoen B, Cabie A, Cheret A, Lahoulou R, Raffi F, Pugliese P, Grp D'AIDSstudy
JournalINFECTIOUS DISEASES
Volume48
Pagination392-398
Date PublishedMAY 3
Type of ArticleArticle
ISSN2374-4235
Mots-clésetravirine, HIV, NNRTI, Tolerability, virological efficacy
Résumé

{Objectives Etravirine (ETR) was approved in France in September 2008 and is used in combination with a boosted protease inhibitor (bPI) and other anti-retrovirals (ART) in HIV-infected pre-treated patients. This study aimed to report in a real-life setting the efficacy and tolerability of ETR-based regimens and factors associated with virological response. Methods The study population included all treatment-experienced patients who initiated an ETR-based regimen between September 2008 and July 2013 from the French Dat'AIDS cohort. Analyses were performed in ART-experienced patients starting ETR after virological failure (VF) or as a maintenance therapy (MT), with or without bPI. Results A total of 2006 patients (VF

DOI10.3109/23744235.2015.1133927