High prevalence of psychiatric disorders in patients with skin-restricted lupus: a case-control study

{Background Psychiatric disorders have been extensively ciocurnented in patients with systemic lupus erythernatostis (SLE). However, the prevalence of psychiatric disorders in patients with skin-restricted lupus (SRL) remains unknown, although SRL is rnore common than SLO. Objectives To assess current and lifetime prevalence of Axis I psychiatric disorders among outpatients with SRL and to examine the factors associated with psychiatric disorders among such patients. Methods A multicentre case control study involving outpatients with SRL and controls matched for sex, age and education level. The Mini International Neuropsy chiatric Interview was used for psychiatric evaluation. Results We evaluated 75 patients and 150 controls. Of these, 49% of patients vs. 13% of controls fulfilled the criteria for at least one current psychiatric disorder (P < 0.001). The following disorders were significantly more frequent among patients than controls: current and lifetime major depressive disorder (9% vs. 0%, P < 0.001 and 44% vs. 26%