Late Persistent Positive EBV Viral Load and Risk of Solid Cancer in Kidney Transplant Patients

Affiliation auteurs!!!! Error affiliation !!!!
TitreLate Persistent Positive EBV Viral Load and Risk of Solid Cancer in Kidney Transplant Patients
Type de publicationJournal Article
Year of Publication2017
AuteursBamoulid J, Courivaud C, Coaquette A, Crepin T, Carron C, Gaiffe E, Roubiou C, Rebibou J-M, Ducloux D
JournalTRANSPLANTATION
Volume101
Pagination1473-1478
Date PublishedJUN
Type of ArticleArticle
ISSN0041-1337
Résumé

{Background. Recent studies reported that posttransplant Epstein-Barr virus (EBV) replication is frequent and indicates overimmunosuppression. We hypothesized that long-term EBV replication may identify overimmunosuppressed patients at higher risk of cancer. Methods. We analyzed a prospective cohort of renal transplant recipients having routine EBV FOR surveillance. All cancers (except EBV-related neoplasia) were recorded. Results. Mean follow up was 94 + 23 months. Samples (8412) were available in 669 patients. Three hundred eighty-eight of the 669 patients (58%) had at least 1 positive viremia during follow-up. Epstein-Barr virus D+/R- patients (P = 0.046) as well as those having received antithymocyte globulin (P < 0.001) were more likely to develop persistent EBV viremia. Eighty-six patients (12.9%) developed a cancer during follow-up. The cumulated incidence of cancer was higher in patients with persistent high EBV replication (22.4% vs 10.2%
DOI10.1097/TP.0000000000001280