Effect of Corticosteroids on Facial Function after Cerebellopontine Angle Tumor Removal: A Double-Blind Study versus Placebo
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Effect of Corticosteroids on Facial Function after Cerebellopontine Angle Tumor Removal: A Double-Blind Study versus Placebo |
| Type de publication | Journal Article |
| Year of Publication | 2015 |
| Auteurs | Grayeli ABozorg, Ferrary E, Tubach F, Bernat I, Deguine O, Darrouzet V, Robier A, Zaouche S, Dubreuil C, Marx M, Kalamarides M, Fraysse B, Sterkers O |
| Journal | AUDIOLOGY AND NEURO-OTOLOGY |
| Volume | 20 |
| Pagination | 213-221 |
| Type of Article | Article |
| ISSN | 1420-3030 |
| Mots-clés | Cerebellopontine angle surgery, Facial palsy, Nerve trauma, Steroids, Vestibular schwannoma |
| Résumé | The aim of this study was to assess the effect of corticosteroids administered intra-and postoperatively on the occurrence of facial palsy after a cerebellopontine angle (CPA) tumor resection, and to investigate pre- and intraoperative prognostic factors. A multicenter, prospective, randomized, double-blind and versus-placebo study was conducted between 2006 and 2010. Three hundred and ten patients operated on for a CPA tumor (96% vestibular schwannomas, 4% miscellaneous) were included by five participating centers. The population was stratified into patients with small (<= 15 mm CPA on axial MRI views) and large tumors. In each group, patients were randomized to receive corticosteroid (1 mg/kg/day i.v. methylprednisolone intraoperatively and at postoperative days 1-5) or placebo. Steroids did not affect the facial function at postoperative days 1, 8 and 30 in patients with small or large tumors as evaluated by House and Brack-mann grading. (C) 2015 S. Karger AG, Basel |
| DOI | 10.1159/000370191 |