Validity of the global anti-phospholipid syndrome score to predict thrombosis: a prospective multicentre cohort study

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TitreValidity of the global anti-phospholipid syndrome score to predict thrombosis: a prospective multicentre cohort study
Type de publicationJournal Article
Year of Publication2015
AuteursZuily S, de Laat B, Mohamed S, Kelchtermans H, Shums Z, Albesa R, Norman GL, Lamboux-Matthieu C, Rat A-C, Ninet J, Magy-Bertrand N, Pasquali J-L, Lambert M, Lorcerie B, Kaminsky P, Guillemin F, Regnault V, Wahl D, Investigators TACIT
JournalRHEUMATOLOGY
Volume54
Pagination2071-2075
Date PublishedNOV
Type of ArticleArticle
ISSN1462-0324
Mots-clésanti-phosphatidylserine/prothrombin antibodies, Antiphospholipid syndrome, global APS score, Systemic lupus erythematosus, thrombosis
Résumé

{Objective. To investigate the validity of the global APS score (GAPSS) to predict thrombosis in patients with autoimmune diseases. Methods. This prospective cohort study included consecutive patients with aPL or SLE. aPL, aPS-PT and GAPSS were determined. A Cox proportional hazards model assessed the validity of GAPSS and identified other potential independent predictors of thrombosis. Results. One hundred and thirty-seven patients [43.5 (S.D. 15.4) years old; 107 women] were followed up for a mean duration of 43.1 (S.D. 20.7) months. Mean GAPSS was significantly higher in patients who experienced a thrombotic event compared with those without [10.88 (S.D. 5.06) vs 8.15 (S.D. 5.31), respectively

DOI10.1093/rheumatology/kev238