Fast-Growing Alveolar Echinococcosis Following Lung Transplantation

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TitreFast-Growing Alveolar Echinococcosis Following Lung Transplantation
Type de publicationJournal Article
Year of Publication2020
AuteursDupont C, Grenouillet F, Mabrut J-Y, Gay F, Persat F, Wallon M, Mornex J-F, Philit F, Dupont D
JournalPATHOGENS
Volume9
Pagination756
Date PublishedSEP
Type of ArticleArticle
Mots-clésEchinococcus multilocularis, immunosuppression, Liver, lung transplantation, parasite
Résumé

Alveolar echinococcosis is a rare but life-threatening infection caused by the parasiteEchinococcus multilocularis. Its natural history is characterized by a slow parasitic growth over several years. Increased incidence and shorter development delay have been reported in immune-compromised patients. We report the reactivation of aborted lesions within 12 months of lung transplantation leading to a fast-growing aggressive hepatic lesion. Timely identification of alveolar echninococcosis allowed prompt albendazole treatment and radical surgery leading to a favorable outcome 42 months after transplantation. However, close clinical, serological and radiological monitoring is required to rule out relapses in the long term. The pre-existence of aborted self-limited lesions of alveolar echinococcosis and the possibility for their atypical rapid growth in patients undergoing profound immunosuppression should be known by healthcare providers, even if working in non-endemic areas.

DOI10.3390/pathogens9090756