A Standard Numbering Scheme for Class C beta-Lactamases
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | A Standard Numbering Scheme for Class C beta-Lactamases |
| Type de publication | Journal Article |
| Year of Publication | 2020 |
| Auteurs | Mack AR, Barnes MD, Taracila MA, Hujer AM, Hujer KM, Cabot G, Feldgarden M, Haft DH, Klimke W, van den Akker F, Vila AJ, Smania A, Haider S, Papp-Wallace KM, Bradford PA, Rossolini GMaria, Docquier J-D, Frere J-M, Galleni M, Hanson ND, Oliver A, Plesiat P, Poirel L, Nordmann P, Palzkill TG, Jacoby GA, Bush K, Bonomo RA |
| Journal | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY |
| Volume | 64 |
| Pagination | e01841-19 |
| Date Published | MAR |
| Type of Article | Article |
| ISSN | 0066-4804 |
| Mots-clés | amino acid numbering, AmpC, beta-lactamases, class C beta-lactamase, conserved residue, Nomenclature, structure-activity relationships |
| Résumé | Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) beta-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser(64), Lys(67), Tyr(150), and Lys(315)), is adaptable to new variants or enzymes yet to be discovered and includes a variation for genetic and epidemiological applications. |
| DOI | 10.1128/AAC.01841-19 |