Pneumonia in acute ischemic stroke patients requiring invasive ventilation: Impact on short and long-term outcomes
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Titre | Pneumonia in acute ischemic stroke patients requiring invasive ventilation: Impact on short and long-term outcomes |
Type de publication | Journal Article |
Year of Publication | 2019 |
Auteurs | de Montmollin E, Ruckly S, Schwebel C, Philippart F, Adrie C, Mariotte E, Marcotte G, Cohen Y, Sztrymf B, da Silva D et al. |
Journal | JOURNAL OF INFECTION |
Volume | 79 |
Pagination | 220-227 |
Date Published | SEP |
Type of Article | Article |
ISSN | 0163-4453 |
Mots-clés | Critical care, epidemiology, Mechanical ventilation, Mortality, Pneumonia, Stroke |
Résumé | {Objectives: To describe the epidemiology and prognostic impact of pneumonia in acute ischemic stroke patients requiring invasive mechanical ventilation. Methods: Retrospective analysis from a prospective multicenter cohort study of critically ill patients with acute ischemic stroke requiring invasive mechanical ventilation at admission. Impact of pneumonia was investigated using Cox regression for 1-year mortality, and competing risk survival models for ICU mortality censored at 30-days. Results: We included 195 patients. Stroke was supratentorial in 62% and 64% of patients had a Glasgow coma scale score <8 on admission. Mortality at day-30 and 1 year were 56%, and 70%, respectively. Post-stroke pneumonia was identified in 78 (40%) patients, of which 46/78 (59%) episodes were present at ICU admission. Post-stroke pneumonia was associated with an increase in 1-year mortality (adjusted HR 1.49, 95% CI [1.01-2.20]). Post-stroke pneumonia was not associated with ICU mortality but was associated with a 1.6-fold increase in ICU length of stay (CSHR 0.62 [0.39-0.99] |
DOI | 10.1016/j.jinf.2019.06.012 |