A genome-wide association study identifies susceptibility loci for primary central nervous system lymphoma at 6p25.3 and 3p22.1: a LOC Network study

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TitreA genome-wide association study identifies susceptibility loci for primary central nervous system lymphoma at 6p25.3 and 3p22.1: a LOC Network study
Type de publicationJournal Article
Year of Publication2019
AuteursLabreche K, Daniau M, Sud A, Law PJ, Royer-Perron L, Holroyd A, Broderick P, Went M, Benazra M, Ahle G, Soubeyran P, Taillandier L, Chinot OL, Casasnovas O, Bay J-O, Jardin F, Oberic L, Fabbro M, Damaj G, Brion A, Mokhtari K, Philippe C, Sanson M, Houillier C, Soussain C, Hoang-Xuan K, Houlston RS, Alentorn A, Moles-Moreau M-P, Gressin R, Delwail V, Morschhauser F, Agape P, Jaccard A, Ghesquieres H, Tempescul A, Gyan E, Marolleau J-P, Houot R, Fornecker L, Di Stefano A-L, Detrait I, Rahimian A, Lathrop M, Genet D, Davi F, Cassoux N, Touitou V, Choquet S, Vital A, Polivka M, Figarella-Branger D, Benouaich-Amiel A, Campello C, Charlotte F, Martin-Duverneuil N, Feuvret L, Kas A, Navarro S, Villa C, Bielle F, Chretien F, Tortel MChristine, Gauchotte G, Uro-Coste E, Godfrain C, Rigau V, Costopoulos M, Le Garff-Tavernier M, Meyronnet D, Rousseau A, Adam C, Lamy T, Chabrot C, Boyle EM, Blonski M, Schmitt A, Network LOC
JournalNEURO-ONCOLOGY
Volume21
Pagination1039-1048
Date PublishedAUG
Type of ArticleArticle
ISSN1522-8517
Mots-cléscancer susceptibility, GWAS, primary CNS lymphoma
Résumé

{Background. Primary central nervous system lymphoma (PCNSL) is a rare form of extra-nodal non-Hodgkin lymphoma. PCNSL is a distinct subtype of non-Hodgkin lymphoma, with over 95% of tumors belonging to the diffuse large B-cell lymphoma (DLBCL) group. We have conducted a genome-wide association study (GWAS) on immunocompetent patients to address the possibility that common genetic variants influence the risk of developing PCNSL. Methods. We performed a meta-analysis of 2 new GWASs of PCNSL totaling 475 cases and 1134 controls of European ancestry. To increase genomic resolution, we imputed >10 million single nucleotide polymorphisms using the 1000 Genomes Project combined with UK10K as reference. In addition we performed a transcription factor binding disruption analysis and investigated the patterns of local chromatin by Capture Hi-C data. Results. We identified independent risk loci at 3p22.1 (rs41289586, ANO10
DOI10.1093/neuonc/noz088