Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients

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TitreInvasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients
Type de publicationJournal Article
Year of Publication2019
AuteursBellanger A-P, Berceanu A, Scherer E, Desbrosses Y, Daguindau E, Rocchi S, Millon L
JournalEMERGING INFECTIOUS DISEASES
Volume25
Pagination1778-1779
Date PublishedSEP
Type of ArticleLetter
ISSN1080-6040
Résumé

We present 2 fatal cases of invasive fungal disease with isavuconazole treatment failure in immunocompromised patients: one with a TR34-L98H azole-resistant Aspergillus fumigatus isolate and the other a Rhizomucor-A. fumigatus co-infection. Such patients probably require surveillance by galactomannan antigen detection and quantitative PCRs for A. fumigatus and Mucorales fungi.

DOI10.3201/eid2509.190598