Pneumonia-Specific Escherichia coli with Distinct Phylogenetic and Virulence Profiles, France, 2012-2014

Affiliation auteurs!!!! Error affiliation !!!!
TitrePneumonia-Specific Escherichia coli with Distinct Phylogenetic and Virulence Profiles, France, 2012-2014
Type de publicationJournal Article
Year of Publication2019
AuteursLa Combe B, Clermont O, Messika J, Eveillard M, Kouatchet A, Lasocki S, Corvec S, Lakhal K, Billard-Pomares T, Fernandes R, Armand-Lefevre L, Bourdon S, Reignier J, Fihman V, de Prost N, Bador J, Goret J, Wallet F, Denamur E, Ricard J-D, Branger C, Landraud L, Bleibtreu A, Jaureguy F, Asfar P, Dreyfuss D, Barnaud G, Magdoud F, Wolff M, Timsit J-F, Martin S, Charles P-E, Boyer A, Jaillette E, Nseir S, Ruimy R, Danin P-E, Dellamonica J, Cremniter J, Frat J-P, Clec'h C, Decre D, Maury E, Grp COLOCOLI
JournalEMERGING INFECTIOUS DISEASES
Volume25
Pagination710-718
Date PublishedAPR
Type of ArticleArticle
ISSN1080-6040
Résumé

In a prospective, nationwide study in France of Escherichia coli responsible for pneumonia in patients receiving mechanical ventilation, we determined E. coli antimicrobial susceptibility, phylotype, O-type, and virulence factor gene content. We compared 260 isolates with those of 2 published collections containing commensal and bacteremia isolates. The preponderant phylogenetic group was B2 (59.6%), and the predominant sequence type complex (STc) was STc73. STc127 and STc141 were overrepresented and STc95 underrepresented in pneumonia isolates compared with bacteremia isolates. Pneumonia isolates carried higher proportions of virulence genes sfa/foc, papGIII, hlyC, cnf1, and iroN compared with bacteremia isolates. Virulence factor gene content and antimicrobial drug resistance were higher in pneumonia than in commensal isolates. Genomic and phylogenetic characteristics of E. coil pneumonia isolates from critically ill patients indicate that they belong to the extraintestinal pathogenic E. coli pathovar but have distinguishable lung-specific traits.
DOI10.3201/eid2504.180944