Clinical spectrum, evolution, and management of autoimmune cytopenias associated with angioimmunoblastic T-cell lymphoma
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Clinical spectrum, evolution, and management of autoimmune cytopenias associated with angioimmunoblastic T-cell lymphoma |
| Type de publication | Journal Article |
| Year of Publication | 2019 |
| Auteurs | Crickx E, Poullot E, Moulis G, Goulabchand R, Fieschi C, Galicier L, Meignin V, Coppo P, Delarue R, Casasnovas O, Roos-Weil D, de Leval L, Parrens M, Michel M, Dupuis J, Le Bras F, Fataccioli V, Martin-Garcia N, Godeau B, Haioun C, Gaulard P, Mahevas M |
| Journal | EUROPEAN JOURNAL OF HAEMATOLOGY |
| Volume | 103 |
| Pagination | 35-42 |
| Date Published | JUL |
| Type of Article | Article |
| ISSN | 0902-4441 |
| Mots-clés | angioimmunoblastic T-cell lymphoma, autoimmune hemolytic anemia, immune thrombocytopenia, plasmablast, pure red cell aplasia |
| Résumé | {Objective Angioimmunoblastic T-cell lymphoma (AITL) is frequently associated with autoimmune cytopenia (AIC). Whether such patients have a particular phenotype and require particular management is unclear. Method Angioimmunoblastic T-cell lymphoma patients from the multicentric database of the Lymphoma Study Association presenting with AIC during disease course were included and matched to AITL patients without AIC (1/5 ratio). Results At diagnosis, AIC patients (n = 28) had more spleen and bone marrow involvement (54% vs 19% and 71% vs 34%, P < 0.001), Epstein-Barr virus replication (89% vs 39%, P < 0.001), gamma globulin titers (median 23 vs 15 g/L |
| DOI | 10.1111/ejh.13239 |