Quality and determinants of anticoagulation therapy by AVK in elderly subjects: study of a continuous series of 155 patients hospitalized in geriatric medicine

{Objective. AVK could be prescribed in elderly patients over 75 years for the prevention of thromboembolic complications of atrial fibrillation (AF). The objective of this study was to study the quality of the anticoagulation balance by AVK and its determinants. Method. Inclusion of all patients >= 75 years of age treated with AVK for an AF hospitalized in the acute geriatric department of the University hospital of Dijon. The balance of the AVK treatment was determined by the input INR and the calculation of the TTR. The last four INRs prior to admission were retrospectively collected for its calculation. Each patient had a standardized geriatric evaluation (EGS): lifestyle, MMSE, nutritional status (albumin), polypathology (Charlson), level of dependence (ADL-IADL). Bleeding complication were collected. Results. 155 patients aged over 75 years (87 +/- 5.6 years, 88 women and 67 men) were included. The mean TTR was 55.4 +/- 31.2%. Only 46% of patients had a correct TTR (>= 75%). The balance was significantly worse in women than in men (49.3 +/- 29.5 vs 60.1 +/- 31.8%; p=0.0326), and in case of haematological pathology (41.7 +/- 27.1 vs 57.2 +/- 9.8; p=0.047) but better with high BMI (r=0.416