Prognostic factors of survival in HIV/HCV co-infected patients with hepatocellular carcinoma: The CARCINOVIC Cohort

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TitrePrognostic factors of survival in HIV/HCV co-infected patients with hepatocellular carcinoma: The CARCINOVIC Cohort
Type de publicationJournal Article
Year of Publication2019
AuteursGelu-Simeon M, Lewin M, Ostos M, Bayan T, Delgado MBeso, Teicher E, Layese R, Roudot-Thoraval F, Fontaine H, Sobesky R et al.
JournalLIVER INTERNATIONAL
Volume39
Pagination136-146
Date PublishedJAN
Type of ArticleArticle
ISSN1478-3223
Mots-cléshepatocellular carcinoma, HIV/HCV co-infected patients, prognostic factors, therapeutic strategy
Résumé

{Background & Aims HIV/HCV co-infected patients with hepatocellular carcinoma (HCC) have poorer survival than HCV mono-infected patients. We aimed to evaluate the prognostic factors for survival. Methods From 2006 to 2013, 55 incident HCCs among HIV+/HCV+ patients, from three ANRS cohorts, were compared with 181 HCCs in HIV-/HCV+ patients from the ANRS Cirvir cohort. Results HIV+/HCV+ patients were younger (50 years [IQR: 47-53] vs 62 [54-70], P < 0.001), male (89% vs 63%, P < 0.001) than HIV-/HCV+ patients. At HCC diagnosis, both groups had a majority of non-responders to anti-HCV-therapy, and HIV+/HCV+ patients had more frequently known a previous cirrhosis decompensation (31% vs 14%
DOI10.1111/liv.13921