Severe liver failure rather than cirrhosis is associated with mortality in patients with infectious endocarditis: a retrospective case-control study

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TitreSevere liver failure rather than cirrhosis is associated with mortality in patients with infectious endocarditis: a retrospective case-control study
Type de publicationJournal Article
Year of Publication2018
AuteursAllaire M, Cadranel J-FD, Bureau C, Zerkly S, Thevenot T, Garioud A, Cacoub P, Macaigne G, Alric L, Jouannaud V, Lison H, Chagneau-Derrode C, Pariente A, Pelaquier A, Bourliere M, Causse X, Nousbaum J-B, Dumortier J, Louvet A, Rosa-Hezode I, Ganne-Carrie N, Chentouh R, Sfaxi A, Gournay J, Blasco-Perrin H, Antonini T, Spahr L, Bronowicki J-P, Silvain C, Di Martino V, Grange J-D, Denis J, Dupont K, Iaria P, Ollivier-Hourmand I, Dao T, Gastroenterologist FAssoc
JournalEUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
Volume30
Pagination1216-1223
Date PublishedOCT
Type of ArticleArticle
ISSN0954-691X
Mots-clésCardiac surgery, case-control study, cirrhosis, infectious endocarditis, prognostic factors
Résumé

{BackgroundData on infectious endocarditis (IE) in patients with liver cirrhosis (LC) are sparse. We aimed to describe the characteristics and predictors of mortality from IE in patients with LC.Patients and methodsOverall, 101 patients with LC and 101 controls with IE matched for sex, age, date of IE, and diabetes were retrospectively selected in 23 liver units between 2000 and 2013.ResultsMean age was 60.810.5 and 60.6 +/- 11.5 years in LC and controls, respectively. Causes of cirrhosis (Child-Pugh A/B/C: 10.4%/41.7%/47.9%, MELD score: 17 +/- 7.8) were excess alcohol intake (79.6%), viral hepatitis (17.3%), and metabolic syndrome (14.3%). Previous history of cardiopathy was found in 24.8% of LC (prosthetic valve 8.9%) and 37.6% of controls (P=0.07). The most frequent bacteria involved were gram-positive cocci. LC had significantly fewer aminoglycosides (P=0.0007), rifamycin (P=0.03), and valve surgery (P=0.02) than controls. The proportion of patients who died following cardiac surgery was similar between the two groups (9.7% for LC vs. 8.7% for controls
DOI10.1097/MEG.0000000000001155