Intravenous Busulfan Compared with Treosulfan-Based Conditioning for Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia: A Study on Behalf of the Acute Leukemia Working Party of European Society for Blood and Marrow Transplantation

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TitreIntravenous Busulfan Compared with Treosulfan-Based Conditioning for Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia: A Study on Behalf of the Acute Leukemia Working Party of European Society for Blood and Marrow Transplantation
Type de publicationJournal Article
Year of Publication2018
AuteursShimoni A, Labopin M, Savani B, Hamladji R-M, Beelen D, Mufti G, Socie G, Delage J, Blaise D, Chevallier P, Forcade E, Deconinck E, Mohty M, Nagler A
JournalBIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
Volume24
Pagination751-757
Date PublishedAPR
Type of ArticleArticle
ISSN1083-8791
Mots-clésacute myeloid leukemia, busulfan, stem cell transplantation, Treosulfan
Résumé

{Dose intensity of the conditioning regimen has significant impact on the outcomes after stem cell transplantation (SCT) for acute myeloid leukemia. Most studies have shown more relapse, less nonrelapse mortality (NRM), and similar overall survival after reduced-intensity and myeloablative conditioning. There are limited data on the dose equivalence and expected outcomes of treosulfan-based compared with busulfan-based conditioning. We compared SCT outcomes after fludarabine with either intravenous busulfan at a myeloablative dose (FB4, 12.8 mg/kg
DOI10.1016/j.bbmt.2017.12.776