Clinical and dosimetric study of radiotherapy for glioblastoma: three-dimensional conformal radiotherapy versus intensity-modulated radiotherapy

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TitreClinical and dosimetric study of radiotherapy for glioblastoma: three-dimensional conformal radiotherapy versus intensity-modulated radiotherapy
Type de publicationJournal Article
Year of Publication2018
AuteursThibouw D, Truc G, Bertaut A, Chevalier C, Aubignac L, Mirjolet C
JournalJOURNAL OF NEURO-ONCOLOGY
Volume137
Pagination429-438
Date PublishedAPR
Type of ArticleArticle
ISSN0167-594X
Mots-clés3D conformational radiation therapy, clinical outcomes, Dosimetric outcomes, Glioblastoma, Intensity-modulated radiation therapy
Résumé

{We aimed to compare three-dimensional conformal radiotherapy (3D-CRT) with intensity-modulated radiotherapy (IMRT) for the treatment of glioblastoma. Retrospective study of 220 patients with glioblastoma, treated with 3D-CRT or IMRT, with or without surgery. Dosimetric parameters as well as clinical and survival data for the two techniques were analyzed and compared. The median conformity index was 1.53 (range 0-2.69) for 3D-CRT and 1.25 (range 0.97-2.01) for IMRT, p < 10(-4). The median homogeneity index was 0.10 (range 0.03-0.32) for 3D-CRT and 0.07 (range 0.03-0.18) for IMRT, p < 10(-4). There were significantly fewer acute grade 1 and 2 neurological toxicities in the IMRT group especially for edema (1.3 versus 12.4%
DOI10.1007/s11060-017-2735-y