Safety of sofosbuvir-based regimens after liver transplantation: longitudinal assessment of renal function in the prospective ANRS CO23 CUPILT study

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TitreSafety of sofosbuvir-based regimens after liver transplantation: longitudinal assessment of renal function in the prospective ANRS CO23 CUPILT study
Type de publicationJournal Article
Year of Publication2018
AuteursAnty R., Favre G., Coilly A., Rossignol E., Houssel-Debry P., Duvoux C., De Ledinghen V, Di Martino V, Leroy V, Radenne S., Komar N., Canva V, D'alteroche L., Durand F., Dumortier J., Lebray P., Besch C., Tran A., Canivet C.M, Botta-Fridlund D., Montialoux H., Moreno C., Conti F., Silvain C., Perre P., Habersetzer F., Abergel A., Debette-Gratien M., Dharancy S., Esnault V.LM, Fougerou-Leurent C., Cagnot C., Diallo A., Veislinger A., Danjou H., Samuel D., Pageaux G-P, Duclos-Vallee J-C, Grp ANRSCO23 CUPIL
JournalALIMENTARY PHARMACOLOGY & THERAPEUTICS
Volume47
Pagination1682-1689
Date PublishedJUN
Type of ArticleArticle
ISSN0269-2813
Résumé

{Background: In liver transplant recipients with hepatitis C virus recurrence, there is concern about renal safety of sofosbuvir-based regimens. Changes in serum creatinine or in the estimated glomerular filtration rate (eGFR) under treatment are used to look for possible renal toxicity. However, serum creatinine and eGFR are highly variable. Aim: To analyse renal function trajectory with numerous assays of serum creatinine over a long period of time. Methods: In a multicentre cohort of 139 patients, the eGFR was obtained from serum creatinine using the Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation. Slopes of eGFR were defined as a change in eGFR during a period divided by time. Pre-treatment, on-treatment and post-treatment periods were 9 months, 3-9 months and 4.5 months. Interactions between eGFR slopes and the pre-treatment eGFR, use of ribavirin or mycophenolate mofetil, and stage of fibrosis were addressed. On-treatment eGFR slopes were separated in tertiles. Pre- and post-treatment eGFR slopes were compared globally and according to tertiles. Results: The post-treatment eGFR slope was significantly better than pre-treatment eGFR slope (+0.18 (IQR -0.76 to +1.32) vs -0.11 (IQR -1.01 to +0.73) mL/min/1.73 m(2)/month
DOI10.1111/apt.14639