Umbilical Cord Blood Cytomegalovirus Serostatus Does Not Have an Impact on Outcomes of Umbilical Cord Blood Transplantation for Acute Leukemia

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TitreUmbilical Cord Blood Cytomegalovirus Serostatus Does Not Have an Impact on Outcomes of Umbilical Cord Blood Transplantation for Acute Leukemia
Type de publicationJournal Article
Year of Publication2017
AuteursNikolajeva O, Rocha V, Danby R, Ruggeri A, Volt F, Baudoux E, Gomez SG, Koegler G, Larghero J, Lecchi L, Martinez MSanchez, Navarrete C, Pouthiers F, Querol S, Kenzey C, Szydlo R, Gluckman E, Madrigal A
JournalBIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
Volume23
Pagination1729-1735
Date PublishedOCT
Type of ArticleArticle
ISSN1083-8791
Mots-clésacute leukemia, cytomegalovirus, transplantation, Umbilical cord blood
Résumé

{Several studies have reported an impact of adult hematopoietic stem cell donor cytomegalovirus (CMV) serostatus on allogeneic hematopoietic cell transplantation outcomes. Limited data, however, are available on the impact of cord blood unit (CBU) CMV serostatus on allogeneic umbilical cord blood transplantation (UCBT) outcomes. We analyzed, retrospectively, the impact of CBU CMV serostatus on relapse incidence (RI) and 2-year nonrelapse mortality (NRM) of single-unit CBU transplantation for acute leukemia. Data from 1177 de novo acute leukemia pediatric and adult patients transplanted within European Group for Blood and Marrow Transplantation centers between 2000 and 2012 were analyzed. CBUs were provided by the European Cord Blood Banks. The median follow-up time for live patients was 59.9 months. The recipients of CMV-seropositive and -seronegative CBUs showed a comparable RI (33% versus 35%, respectively
DOI10.1016/j.bbmt.2017.06.022