Association between lung cancer somatic mutations and occupational exposure in never-smokers
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Association between lung cancer somatic mutations and occupational exposure in never-smokers |
| Type de publication | Journal Article |
| Year of Publication | 2017 |
| Auteurs | Paris C, Do P, Mastroianni B, Dixmier A, Dumont P, Pichon E, Chouaid C, Coudert B, Foucher P, Fraboulet S, Locatelli-Sanchez M, Baize N, Dansin E, Moreau L, Vincent M, Missy P, Morin F, Moro-Sibilot D, Couraud S, Investig BCASIFCT-1002 |
| Journal | EUROPEAN RESPIRATORY JOURNAL |
| Volume | 50 |
| Pagination | 1700716 |
| Date Published | OCT 1 |
| Type of Article | Article |
| ISSN | 0903-1936 |
| Résumé | {Occupational exposure constitutes a common risk factor for lung cancer. We observed molecular alterations in 73% of never-smokers, 35% of men and 8% of women were exposed to at least one occupational carcinogen. We report herein associations between molecular patterns and occupational exposure. BioCAST was a cohort study of lung cancer in never-smokers that reported risk factor exposure and molecular patterns. Occupational exposure was assessed via a validated 71-item questionnaire. Patients were categorised into groups that were unexposed and exposed to polycyclic aromatic hydrocarbons (PAH), asbestos, silica, diesel exhaust fumes (DEF), chrome and paints. Test results were recorded for EGFR, KRAS, HER2, BRAF and PIK3 mutations, and ALK alterations. Overall, 313 out of 384 patients included in BioCAST were analysed. Asbestos-exposed patients displayed a significantly lower rate of EGFR mutations (20% versus 44% |
| DOI | 10.1183/13993003.00716-2017 |