Bacterial infection in compensated viral cirrhosis impairs 5-year survival (ANRS CO12 CirVir prospective cohort)
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Bacterial infection in compensated viral cirrhosis impairs 5-year survival (ANRS CO12 CirVir prospective cohort) |
| Type de publication | Journal Article |
| Year of Publication | 2017 |
| Auteurs | Nahon P, Lescat M, Layese R, Bourcier V, Talmat N, Allam S, Marcellin P, Guyader D, Pol S, Larrey D, de Ledinghen V, Ouzan D, Zoulim F, Roulot D, Tran A, Bronowicki J-P, Zarski J-P, Goria O, Cales P, Peron J-M, Alric L, Bourliere M, Mathurin P, Blanc J-F, Abergel A, Serfaty L, Mallat A, Grange J-D, Attali P, Bacq Y, Wartelle C, Dao T, Benhamou Y, Pilette C, Silvain C, Christidis C, Capron D, Bernard-Chabert B, Hillaire S, Di Martino V, Trinchet J-C, Moreau R, Roudot-Thoraval F, Grp ANRSCO12 CirVi |
| Journal | GUT |
| Volume | 66 |
| Pagination | 330-341 |
| Date Published | FEB |
| Type of Article | Article |
| ISSN | 0017-5749 |
| Résumé | {Objective To assess incidence and prognostic significance of bacterial infections (BIs) occurring in compensated viral cirrhosis. Design This prospective study involved 35 French centres. Inclusion criteria were biopsy-proven HCV or HBV cirrhosis, Child-Pugh A and no previous hepatic complications. Cumulative incidence (CumI) of events was estimated in a competing risks framework. Results 1672 patients were enrolled (HCV 1323, HBV 318, HCV-HBV 31). During a median follow-up of 43 months, 234 BIs occurred in 171 patients (5 year CumI: 12.9%), among whom 14.6% had septic shock. Main localisations included the urinary tract (27.4%), lung (25.2%) and peritoneum (10.7%) (other, 86 (36.7%)). Most BIs occurred as a first event prior to liver decompensation (n=140, 81.8%) and were community-acquired (CA, 84.2%). The risk of BI was higher in patients with HCV than in patients with HBV (5 year CumI: 15.2% vs 5.5% |
| DOI | 10.1136/gutjnl-2015-310275 |